Histological Profile and Risk Factor Analysis of Colonic Polyp: Distal Villous type is Common Predictor of High Grade Cytological Dysplasia
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چکیده
Colorectal polyp may be defined as growth of tissue on the lining of colon and rectum. It is assumed that adenomatous polyp is the most potent precursor of colorectal cancer [1]. Consequently colonoscopic polypectomy can reduce risk of colorectal cancer [2]. All polyps are not cancerous nonetheless large number of colon cancers grow as a consequence of adenomatous polyp [3]. Though colorectal cancer incidence rate is high in western countries, now a days it is reported high in Asian countries too [4].
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ویژگی های اپیدمیولوژیک، کولونوسکوپیک و بافت شناختی پولیپ های کولورکتال
Background and purpose: Colorectal cancer is one of the most common types of cancers worldwide. Most of the times it is superimposed on an adenomatous polyp. Today, colonoscopy is the gold standard screening test for diagnosis of colorectal cancer which prevents developing cancer on the adenocarcinoma sequence path way. The goal of this study was to evaluate the gross and microscopic characteri...
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UNLABELLED Adenomatous polyps are precursor lesions for colorectal carcinoma. The risk of cancer development has been associated with age and size, amount of villous component and high-grade dysplasia of adenomas. The subject-related and adenoma-related risk factors for severely dysplastic lesions were further investigated. PATIENTS AND METHODS The study was performed in 474 men and 339 women...
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BACKGROUND The appropriate application of Endoscopic modalities for polypectomy depends on the likelihood that the adenoma in question harbors invasive cancer. While prior studies have evaluated polyp size and morphology in assessing the risk of malignancy, in recent decay some authorities have paid more attention to dysplasia. All in all, the relative risk of cancer based on polyp distribution...
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Fifty-nine colonic adenomas and 6 hyperplastic colonic polyps were analyzed by single-strand conformation polymorphism analysis for mutations in the adenomatous polyposis coli gene (APC). Frameshifts and premature stop codons in at least one copy of APC were detected in 25 of these adenomas. Five adenomas carried 2 APC mutations. No mutations in APC were found in any of the 6 hyperplastic polyp...
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